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Home > Inhibitors & Agonists > Epigenetics > Histone Methyltransferase (HMTase)

MS049 (hydrochloride)

  Cat. No.:  DC8805   Featured
Chemical Structure
2095432-59-8
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More than 5000 active chemicals with high quality for research!
Field of application
MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 that is active in cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2095432-59-8
Chemical Name: N-methyl-4-(phenylmethoxy)-1-piperidineethanamine,dihydrochloride
Synonyms: MS049 (hydrochloride);MS049 dihydrochloride
SMILES: C1C=C(COC2CCN(CCNC)CC2)C=CC=1.Cl.Cl
Formula: C15H26Cl2N2O
M.Wt: 321.285742282867
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM respectively.
Target: target: PRMT4, PRMT6; IC 50: 34 nM (PRMT4 ), 43 nM (PRMT6 )
In Vitro: MS 049 reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner. MS 049 treatment (72 h exposure) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC50 = 1.4 ± 0.1 μM (n = 3)) in HEK293 cells.
References: c[1]. Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Sep 15.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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