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MX69

  Cat. No.:  DC10074   Featured
Chemical Structure
1005264-47-0
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More than 5000 active chemicals with high quality for research!
Field of application
MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1005264-47-0
Chemical Name: MX 69; MX-69
Synonyms: MX 69; MX-69
SMILES: O=C(O)C1=CC=C(C2C(CC=C3)C3C(C=C(S(=O)(NC4=CC(C)=C(C)C=C4)=O)C=C5)=C5N2)C=C1
Formula: C27H26N2O4S
M.Wt: 474.57
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
In Vivo: MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].
In Vitro: MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC9902 PRIMA-1 PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
DC9257 NSC59984 NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway.The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells.
DC10074 MX69 MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
DC8414 MI-77301 (SAR405838) MI-77301 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
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