DC Chemicals' products qualify for U.S. tariff exemptions. We guarantee no price increases due to customs duties and maintain stable supply, continuing to deliver reliable research solutions to our American clients.
| Cas No.: | 89226-50-6 |
| Synonyms: | Manidipine；CV-4093；Franidipine；(±)-Manidipine |
| SMILES: | O=C(OC)C1=C(C)NC(C)=C(C(OCCN2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)C1C5=CC=CC([N+]([O-])=O)=C5 |
| Formula: | C35H38N4O6 |
| M.Wt: | 610.7 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Manidipine is a dihydropyridine L- and T-type calcium channel blocker.It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively).In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg.Formulations containing manidipine have been used in the treatment of hypertension. |
MSDS
COA
| LOT NO. | DOWNLOAD |
|
|
|
| 2018-0101 |
|