Maropitant|cas 147116-67-4|DC Chemicals

Cas No.:	147116-67-4
Chemical Name:	(1R,2S,3S,4R)-2-benzhydryl-N-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine
Synonyms:	CJ-11,972; CJ 11,972; CJ11,972; CJ-11972; CJ 11972; CJ11972; Maropitant; brand name: Cerenia
SMILES:	CC(C)(C)C1=CC=C(OC)C(CN[C@@H]2[C@H](C(C3=CC=CC=C3)C4=CC=CC=C4)N5CCC2CC5)=C1
Formula:	C₃₂H₄₀N₂O
M.Wt:	468.6728
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Maropitant is a neurokinin (NK1) receptor antagonist. Maropitant is the first NK1 receptor antagonist developed to treat and prevent emesis in dogs. Treatment with 1 mg/kg Maropitant citrate, significantly reduced the size of ulcerative dermatitis (UD) lesions in mice. Intravenous Maropitant decreased (p < 0.05) MAC by 16% (1.74 ± 0.17%). In contrast, epidural administration of either saline or Maropitant did not change (p > 0.05) the MAC (2.17 ± 0.34% and 1.92 ± 0.12%, respectively).

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC47011	Elinzanetant	Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia.
DC46851	Imnopitant	Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .
DC46850	SB 218795	SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
DC42312	Hemokinin 1 (mouse)	Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
DC42311	Neurokinin A TFA	Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
DC42048	Biotin-Substance P	Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
DC41718	[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41717	[Lys5,MeLeu9,Nle10]-NKA(4-10)	[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM.
DC41716	GR 64349 TFA	GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively.
DC41715	GR 94800 TFA	GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively.