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Mifobate

  Cat. No.:  DC28072   Featured
Chemical Structure
76541-72-5
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More than 5000 active chemicals with high quality for research!
Field of application
Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 76541-72-5
Synonyms: SR-202;SR 202;SR202
SMILES: O=P(OC(P(=O)(OC)OC)C1C=CC(Cl)=CC=1)(OC)OC
Formula: C11H17ClO7P2
M.Wt: 358.65
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Rieusset J, et al. A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesityand antidiabetic activity. Mol Endocrinol. 2002 Nov;16(11):2628-44.
Description: Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1].
Target: PPARγ:140 μM (IC50)
In Vivo: Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice[1] Animal Model: Eight-week-old male ob/ob mice[1] Dosage: 400 mg/kg Administration: Feed (food admixture maintained for 20 days) Result: Prevented the time-dependent increase in glucose concentrations.
In Vitro: Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days[1]. Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX)[1].
References: [1]. Rieusset J, et al. A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesityand antidiabetic activity. Mol Endocrinol. 2002 Nov;16(11):2628-44.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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