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| Cas No.: | 56472-29-8 |
| Chemical Name: | 9-Octadecenoic acid, 2-hydroxy-, (9Z)- |
| Synonyms: | 9-Octadecenoic acid, 2-hydroxy-, (9Z)-;2-Hydroxy Oleic Acid;(Z)-2-hydroxyoctadec-9-enoic acid;(9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid;Minerval |
| SMILES: | OC(CCCCCC/C=C/CCCCCCCC)C(O)=O |
| Formula: | C18H34O3 |
| M.Wt: | 298.46076631546 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1]. |
| In Vivo: | Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1]. Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1] Dosage: 600 mg/kg Administration: Oral administration; daily; for 21 days Result: Markedly and significantly inhibited tumour growth. |
| In Vitro: | Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1]. Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 25 μM, 50 μM, 75 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner. Western Blot Analysis[1] Cell Line: Jurkat cells Concentration: 25 μM, 50 μM Incubation Time: 72 hours Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP. |
| References: | [1]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70. |
MSDS
COA
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| 2018-0101 |
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