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N-Desmethyl Pimavanserin

  Cat. No.:  DC28845   Featured
Chemical Structure
639863-77-7
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Field of application
N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 639863-77-7
Chemical Name: N-Desmethyl Pimavanserin
Synonyms: CXL6LOR95E;N-Desmethyl-pimavanserin;n-(4-fluorobenzyl)-n-(piperidin-4-yl)-n'-(4-isobutyloxybenzyl)carbamide;Urea, N-((4-fluorophenyl)methyl)-N'-((4-(2-methylpropoxy)phenyl)methyl)-N-4-piperidinyl-;Unii-cxl6lor95E;AC-279;N-Desmethyl Pimavanserin
SMILES: FC1C=CC(=CC=1)CN(C(NCC1C=CC(=CC=1)OCC(C)C)=O)C1CCNCC1
Formula: C24H32FN3O2
M.Wt: 413.528189659119
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.
Description: N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
In Vitro: The mean plasma half-lives for Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279) are 57 hours and 200 hours, respectively.
References: [1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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