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Enzalutamide carboxylic acid

  Cat. No.:  DC29031   Featured
Chemical Structure
1242137-15-0
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Field of application
Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1242137-15-0
Chemical Name: Enzalutamide Carboxylic Acid
Synonyms: Desmethyl-enzalutamide;Enzalutamide Carboxylic Acid;Enzalutamide carboxylic acid
SMILES: CC1(C)C(=O)N(C2=CC(=C(C=C2)C#N)C(F)(F)F)C(=S)N1C3=CC(=C(C=C3)C(=O)O)F
Formula: C20H13F4N3O3S
M.Wt: 451.394
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist[1].
In Vitro: Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive[1].
References: [1]. van Nuland M, et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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