NPS-2143(SB 262470A )|DC Chemicals|Price|Buy

Cas No.:	284035-33-2
Chemical Name:	NPS-2143
Synonyms:	2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile;NPS-2143;2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;Benzonitrile, 2-chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-;NPS 2143 hydrochloride;NPS 2143;SB 262470A;NPS-2143 (SB262470);BDBM50161093;2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile;(R)-2-chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile;(R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamino)propoxy)benzonitrile;SW219455-1;DB05695;Benzonitrile, 2-chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)-;SB262470;BCP02421;CCG-268751;CHEMBL180672;AKOS025401886;BCPP000077;MFCD04113010;Q20707377;SCHEMBL13597018;s2633;YP1;Z25PJ77W7V;GTPL716;SB-262470;HY-10007;(+)-NPS-2143;MS-27036;2-Chloro-6-[(R)-3-(1,1-dimethyl-2-naphthalen-2-yl-ethylamino)-2-hydroxy-propoxy]-benzonitrile;NPS-2143(SB 262470A );2-Chloro-6-((2R)-3-((1,1-dimethyl-2-(2-naphthalenyl)ethyl)amino)-2-hydroxypropoxy)benzonitrile;SB-262470A;284035-33-2;CS-0319;NS00069698;NCGC00344510-01;DTXSID10426075;UNII-Z25PJ77W7V;2-Chloro-6-[((2R)-3-([1,1-dimethyl-2-(2-naphthalenyl)ethyl]-amino)-2-hydroxypropyl)oxy]benzonitrile hydrochloride;AC-26854;NCGC00344510-02;EX-A017;BRD-K75506300-001-01-6;NPS2143
SMILES:	N#CC1=C(OC[C@@H](CNC(C)(CC2=CC=C3C=CC=CC3=C2)C)O)C=CC=C1Cl
Formula:	C₂₄H₂₅N₂O₂Cl
M.Wt:	408.9205
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. NPS 2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50 of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP Formation. In HEK-293 cells transiently expressing hCaSRs, NPS 2143 significantly suppresses the kokumi taste by effectively inhibiting the activity of both GSH (data not shown) and γ-Glu-Val-Gly. A recent study shows that NPS 2143 treatment suppresses low molecular weight fractions of azuki hydrolysate-induced cholecystokinin (CCK) secretion in CaSR-transfected HEK 293 cells. In rats, NPS 2143 results in a rapid 4- to 5-fold increase in plasma PTH levels and also a transient increase in plasma Ca2+ levels. In normotensive rats, NPS 2143 administration (1 mg/kg) by i.v. markedly increases mean arterial blood pressure (MAP) in the presence of parathyroid glands. For the detailed information of NPS-2143(SB 262470A ), the solubility of NPS-2143(SB 262470A ) in water, the solubility of NPS-2143(SB 262470A ) in DMSO, the solubility of NPS-2143(SB 262470A ) in PBS buffer, the animal experiment (test) of NPS-2143(SB 262470A ), the cell expriment (test) of NPS-2143(SB 262470A ), the in vivo, in vitro and clinical trial test of NPS-2143(SB 262470A ), the EC50, IC50,and Affinity of NPS-2143(SB 262470A ), Please contact DC Chemicals.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC60813	NPS-2143(SB 262470A )	NPS-2143(SB 262470A ) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively.