NSC305787
Cat. No.: DC8715
Chemical Structure
785718-37-8
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Field of application
NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.
| Cas No.: |
785718-37-8 |
| Synonyms: |
NSC-305787 |
| SMILES: |
OC(C1NCCCC1)C2=CC(C3(C4)CC5CC4CC(C5)C3)=NC6=C(Cl)C=C(Cl)C=C26 |
| Formula: |
C25H30Cl2N2O |
| M.Wt: |
445.42 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin.in vitro: NSC305787 demonstrates a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis. Both NSC305787 and NSC668394 inhibited T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels. Both NSC305787 (P = 0.003) significantly inhibits the lung metastases growth of high-ezrin-expressing K7M2 OS cells in this organ culture assay.
in vivo: NSC305787 cause reduced cell motility phenotypes in zebrafish. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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