Home > Products > Novel inhibitors

Nebentan potassium

  Cat. No.:  DC40074  
Chemical Structure
342005-82-7
For research use only. We do not sell to patients.
We match the best price and quality on market.
Email:order@dcchemicals.com  sales@dcchemicals.com
Tel:+86-021-58447131
Get Quotation Now
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 342005-82-7
Chemical Name: Potassium [6-methoxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]{ [(e)-2-phenylvinyl]sulfonyl}azanide
Synonyms: Potassium [6-methoxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]{ [(e)-2-phenylvinyl]sulfonyl}azanide;Carbamodithioic acid, (2-(2-(ethylthio)ethoxy)ethyl)-, monopotassium salt;potassium N-[6-methoxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamidate;LS-50810;N-(Ethoxyethyl)dithiocarbamic acid potassium salt;(2-(2-(Ethylthio)ethoxy)ethyl)carbamodithioic acid monopotassium salt;potassium N-(ethylthioethoxyethyl)dithiocarbamate;Carbamodithioic acid, (2-(2-(ethylthio)ethoxy)ethyl)-, monopotassium salt; potassium N-[6-methoxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-2-phenylethenesulfonamidate; LS-50810; N-(Ethoxyethyl)dithiocarbamic acid potassium salt; (2-(2-(Ethylthio)ethoxy)ethyl)carbamodithioic acid monopotassium salt; potassium N-(ethylthioethoxyethyl)dithiocarbamate;;Nebentan potassium
SMILES: COC1N=C(C2N=CC=CN=2)N=C([N-]S(/C=C/C2C=CC=CC=2)(=O)=O)C=1OC1C=CC=CC=1OC.[K+]
Formula: C24H20KN5O5S
M.Wt: 529.609404563904
Purity: >98%
Sotrage: Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months -20°C1 month
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC41590 Sarafotoxin S6a TFA Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3. Sarafotoxin S6a TFA elicits the pig coronary artery with an EC50 value of 7.5 nM.
DC41589 Sarafotoxin S6a Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3. Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM.
DC40074 Nebentan potassium Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo.
DC40073 Nebentan Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo.
DC11513 Aprocitentan (ACT-132577) Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.
DC8191 Sparsentan(PS433540) Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].
DC72191 Clazosentan Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.
DC71774 Vodudeutentan Vodudeutentan is an endothelin receptor antagonist.
DC71520 Ambrisentan sodium Ambrisentan (BSF 208075) sodium is a selective and orally active ET type A receptor (ETAR) antagonist.
DC49633 BMS-193884 BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor.
X
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Site Map|Privacy PolicyCopyright © 2018-2020 All Rights Reserved. Technical Support:KuuJia