Nutlin-3b|(+)Nutlin-3|MDM2 inhibitor|DC Chemicals

Cas No.:	675576-97-3
Synonyms:	Nutlin-3b,nutlin 3b,nutlin3b,(+)Nutlin-3
SMILES:	N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@@H](C3=CC=C(Cl)C=C3)[C@H]2C2=CC=C(Cl)C=C2)=O)CC1=O
Formula:	C₃₀H₃₀Cl₂N₄O₄
M.Wt:	581.49
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

(+)-Nutlin-3 is arbitrarily referred to as enantiomer b because it appears as the second peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It is 150-fold less potent as an inhibitor of p53-MDM2 interaction than (−)-nutlin-3, demonstrating an IC50 value of 13.6 µM. This inactive enantiomer can serve as a useful control for non-MDM2 related cellular activities. For the detailed information of Nutlin-3b, the solubility of Nutlin-3b in water, the solubility of Nutlin-3b in DMSO, the solubility of Nutlin-3b in PBS buffer, the animal experiment (test) of Nutlin-3b, the cell expriment (test) of Nutlin-3b, the in vivo, in vitro and clinical trial test of Nutlin-3b, the EC50, IC50,and affinity,of Nutlin-3b, For the detailed information of Nutlin-3b, the solubility of Nutlin-3b in water, the solubility of Nutlin-3b in DMSO, the solubility of Nutlin-3b in PBS buffer, the animal experiment (test) of Nutlin-3b, the cell expriment (test) of Nutlin-3b, the in vivo, in vitro and clinical trial test of Nutlin-3b, the EC50, IC50,and affinity,of Nutlin-3b, Please contact DC Chemicals.

MSDS

COA

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2018-0101

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