ORY-1001(Ladademstat)
Cat. No.: DC8541
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Chemical Structure
1431303-72-8
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Field of application
ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.
| Cas No.: |
1431303-72-8 |
| Chemical Name: |
Iadademstat dihydrochloride |
| Synonyms: |
Iadademstat dihydrochloride;ORY-1001(trans);trans-N1-((1R,2S)-2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride;Ladademstat;ORY-1001 dihydrochloride |
| SMILES: |
N([C@@]1([H])CC[C@H](N)CC1)[C@@H]1C[C@H]1C1C=CC=CC=1.Cl |
| Formula: |
C15H23ClN2 |
| M.Wt: |
266.809522867203 |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases. |
| In Vivo: |
ORY-1001 trans reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL[1]. |
| In Vitro: |
ORY-1001 dihydrochloride (RG-6016, Ladademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases. |
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