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| Cas No.: | 114-90-9 |
| Chemical Name: | Obidoxime chloride |
| Synonyms: | Pyridinium,1,1'-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-, chloride (1:2);OBIDOXIME CHLORIDE;OBIDOXIME CHLORIDE,OFF-WHITE SOLID;oxo-[[1-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxymethyl]pyridin-4-ylidene]methyl]azanium,dichloride;1,1′-(Oxydimethylene)bis(pyridinium-4-carbaldoxime) dichloride;Bis(4-formylpyridiniomethyl) ether dioxime;Toxogonin;bh6;bu-6;luh6;lueh6;D009768;Obidoxim;Obidoxime;luh(sub6);toxobidin;TOXOGONIN |
| SMILES: | [Cl-].[Cl-].O(C[N+]1C=CC(/C=N/O)=CC=1)C[N+]1C=CC(/C=N/O)=CC=1 |
| Formula: | C14H16Cl2N4O3 |
| M.Wt: | 359.207840919495 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated[1]. |
| In Vivo: | Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) exhibits a LD50 of 57.7 mg/kg after administration of sarin, and it reduces reduces acute toxicity of sarin was evaluated[1]. Animal Model: NMRI male mice Dosage: 10 mg/kg Administration: Intramuscular injection Result: Was effective in reactivating sarin-inhibited acetylcholinesterase (AChE). |
| References: | [1]. Kassa J,et al. A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.Toxicol Mech Methods. 2015 Mar;25(3):229-33. |
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COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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