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PD-1/PD-L1 inhibitor 2(BMS-202)

  Cat. No.:  DC8381   Featured
Chemical Structure
1675203-84-5
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Field of application
PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM,a useful compound immunomodulator compound.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1675203-84-5
Chemical Name: N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-acetamide
Synonyms: PD-L1 inhibitor 2,PD-1 inhibitor 2,PD1 inhibitor 2,PD 1 inhibitor 2,BMS 202,BMS202
SMILES: C(NCCNCC1=CC=C(OCC2C=CC=C(C3=CC=CC=C3)C=2C)N=C1OC)(=O)C
Formula: C25H29N3O3
M.Wt: 419.52
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BMS-202 is an inhibitor of the PD-1/PD-L1 protein/protein interaction with an IC50 of 18 nM.
In Vitro: BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC8381 PD-1/PD-L1 inhibitor 2(BMS-202) PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM,a useful compound immunomodulator compound.
DC9280 BMS-1 (PD1/PDL1 inhibitor 1) PD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor,IC50 values: 0.006-0.10 μM,a useful immunomodulator compound.
DC10330 PD-1-IN-17 PD-1-IN-17 has CAS#CAS:1673560-66-1, which is a programmed cell death-1 (PD-1) inhibitor. PD-1-IN-17 was first reported in patent WO2015033301A1, (Compound 4), inhibits 92% splenocyte proliferation at 100 nM. PD-1-IN-17 may be related to CA-170 (AUPM170), which is a potent PD-1 inhibitor and curreently under clinical trials.
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