PF06840003
Cat. No.: DC10022
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Chemical Structure
198474-05-4
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Field of application
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.
| Cas No.: |
198474-05-4 |
| Synonyms: |
PF 06840003,PF-06840003 |
| SMILES: |
C1C(C(=O)NC1=O)C2=CNC3=C2C=C(C=C3)F |
| Formula: |
C12H9FN2O2 |
| M.Wt: |
232.21 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor. |
| Target: |
IDO-1 |
| In Vivo: |
PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours[1]. |
| In Vitro: |
PF-06840003 reverses IDO-1-induced T-cell anergy in vitro[1]. |
| References: |
[1]. Tumang J, et al. PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr4863. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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