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Home > Inhibitors & Agonists > GPCR > mGluR

PHCCC

  Cat. No.:  DC9752   Featured
Chemical Structure
179068-02-1
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More than 5000 active chemicals with high quality for research!
Field of application
PHCCC is a Group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 179068-02-1
Chemical Name: N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
SMILES: C1C\2C1(OC3=CC=CC=C3/C2=N\O)C(=O)NC4=CC=CC=C4
Formula: C17H14N2O3
M.Wt: 294.31
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PHCCC is a Group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM).Also a positive allosteric modulator for mGlu4a; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. Displays antiParkinsonian effects in rats in vivo.
Target: target: a Group I metabotropic glutamate receptor antagonist EC 50: 6 uM
In Vivo: 1, PHCCC produced antiparkinsonian efficacy in the reserpinized rat model means a significant level of glutamate is available for the activation of the therapeutically relevant mGluR4. 2, The reference for animal administration is 10 mg/kg.(i.p) 3,PHCCC augmentes in vivo genetic and pharmacological models of absence seizures in rats.
In Vitro: PHCCC potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro.
References: [1]. Marino MJ et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73. [2]. Maj M et al. (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. 2003 Dec;45(7):895-906. [3]. Szczurowska E et al. Positive allosteric modulator of mGluR4 PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. Physiol Res. 2012;61(6):619-28. [4]. Domin H et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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