| Description: |
PRT-060318, also known as PRT318 or P142–76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT. (source: Blood. 2011 Feb 17;117(7):2241-6.) For the detailed information of PRT-060318 , the solubility of PRT-060318 in water, the solubility of PRT-060318 in DMSO, the solubility of PRT-060318 in PBS buffer, the animal experiment (test) of PRT-060318 , the cell expriment (test) of PRT-060318 , the in vivo, in vitro and clinical trial test of PRT-060318 , the EC50, IC50,and affinity,of PRT-060318 , Please contact DC Chemicals. |
