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Pim-1 Inhibitor 2

  Cat. No.:  DC8604  
Chemical Structure
477845-12-8
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More than 5000 active chemicals with high quality for research!
Field of application
PIM1-IN-2 is a highly effective and ATP-competitive inhibitor of Pim-1, demonstrating a Ki value of 91 nM. Unlike traditional inhibitors, it interacts with the ATP-binding kinase hinge region without relying on the formation of standard hydrogen bonds, showcasing a unique mechanism of action. This distinctive approach highlights its potential as a promising therapeutic agent.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 477845-12-8
Chemical Name: PIM-1 Inhibitor 2
Synonyms: PIM-1 Inhibitor 2;4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine;4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amine;3bgp;benzisoxazole-pyrimidine,2;PIM1-IN-2;AQVFETGXIRKVAQ-UHFFFAOYSA-N;AQVFETGXIRKVAQ-UHFFFAOYSA-N;VX1;VX1;AKOS005074822;AKOS005074822;NCGC00242499-01;NCGC00242499-01;4-[3-(4-Chlorophenyl)benzo[c]isoxazol-5-yl]pyrimidin-2-ylamine;4-[3-(4-Chlorophenyl)benzo[c]isoxazol-5-yl]pyrimidin-2-ylamine;DB08707;DB08707;benzisoxazole-pyrimidine, 2;benzisoxazole-pyrimidine, 2;HMS3414A13;HMS3414A13;MLS006010772;MLS006010772;10H-944;10H-944;SMR004701461;SMR004701461;QJ8ZMA6BSL;QJ8ZMA6BSL;CS-0029298;CS-0029298;BRD-K48832421-001-01-4;BRD-K48832421-001-01-4;PIM-1 INHIBITOR 2;PIM-1 INHIBITOR 2;PIM-1-Inhibitor-2;PIM-1-Inhibitor-2;PIM-1INHIBITOR2;PIM-1INHIBITOR2;SCHEMBL4031585;SCHEMBL4031585;BDBM26669;BDBM26669;Pim1 inhibitor 2;4-[3-(4-Chlorophenyl)-2,1-benzisoxa zol-5-yl]-2-pyrimidinamine;Pim1 inhibitor 2;2-Pyrimidinamine, 4-(3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl)-;4-[3-(4-Chlorophenyl)-2,1-benzisoxa zol-5-yl]-2-pyrimidinamine;CUA84512;2-Pyrimidinamine, 4-(3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl)-;2-Pyrimidinamine, 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]-;CUA84512;DB-113060;2-Pyrimidinamine, 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]-;477845-12-8;DB-113060;DTXSID30377550;477845-12-8;Q27097893;DTXSID30377550;UNII-QJ8ZMA6BSL;Q27097893;4-(3-(4-Chlorophenyl)-2,1-benzoxazol-5-yl)pyrimidin-2-amine;UNII-QJ8ZMA6BSL;HMS3678A13;4-(3-(4-Chlorophenyl)-2,1-benzoxazol-5-yl)pyrimidin-2-amine;4-[3-(4-chlorophenyl)-benzo[c]isoxazol-5-yl]-pyrimidin-2-ylamine;HMS3678A13;Oprea1_582711;4-[3-(4-chlorophenyl)-benzo[c]isoxazol-5-yl]-pyrimidin-2-ylamine;NS00069054;Oprea1_582711;HY-108605;NS00069054;4-(3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl)-2-pyrimidinamine;HY-108605;HMS3229J19;4-(3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl)-2-pyrimidinamine;PIM 1 Inhibitor 2;HMS3229J19;4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine;PIM 1 Inhibitor 2;CHEMBL409038;4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine;CHEMBL409038
SMILES: C1=C(C=CC(=C1)Cl)C2=C3C=C(C=CC3=NO2)C4=NC(=N)NC=C4
Formula: C17H11ClN4O
M.Wt: 322.74800
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Potent Pim-1 kinase inhibitor (Ki = 91 nM).
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70526 JP-11646 JP-11646 is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively; shows less potency for other kinases in a kinase selectivity panel; exhibits 4-760-fold greater suppression of MM proliferation and viability than ATP-competitive PIM inhibitors; significant reduces tumor burden and increases median survival in xenogeneic myeloma murine models.
DC8604 Pim-1 Inhibitor 2 PIM1-IN-2 is a highly effective and ATP-competitive inhibitor of Pim-1, demonstrating a Ki value of 91 nM. Unlike traditional inhibitors, it interacts with the ATP-binding kinase hinge region without relying on the formation of standard hydrogen bonds, showcasing a unique mechanism of action. This distinctive approach highlights its potential as a promising therapeutic agent.
DC9593 Pim1/AKK1-IN-1 PIM/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively; also inhibits MPSK1 and TNIK.
DC8256 AS 602801(Bentamapimod) AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.
DC10428 (1S,3R,5R)-PIM447 dihydrochloride (1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.
DC71795 Quercetagetin Quercetagetin (6-Hydroxyquercetin), a flavonoid, is a moderately potent and selective, cell-permeable Pim-1 kinase inhibitor with IC50 of 0.34 μM.
DC70675 OX01401 OX01401 (OX-01401, OX1401) is a potent, selective and cell active inhibitor of the PIM kinase family (PIM1 IC50=15.1 nM).OX01401 inhibited proliferation of two PIM-expressing leukaemic cancer cell lines, MV4-11 (IC50=0.5 uM) and PC3 cell (IC50=1.1 uM), and to reduced intracellular phosphorylated 4EBP1 protein in a concentration dependent manner.
DC70081 GDC-0339 GDC-0339 (GDC0339) is a novel small molecule pan-Pim kinase inhibitor that was discovered as a potential treatment for multiple myeloma.
DC48187 PIM-IN-1 PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC50 = 61 nM; pS6, EC50 = 71 nM).
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