| DC1028 |
Y-27632 2HCL
|
Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM. |
| DC6902 |
Thiazovivin
|
Thiazovivin is a rock inhibitor and enhances fibroblast reprogramming efficiency to generate stem cells |
| DC7246 |
SR3677
|
SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM. |
| DC8329 |
SLx-2119(KD-025,Belumosudil )
|
SLx-2119(KD-025) is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM) |
| DC9854 |
SAR407899
|
SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
| DC7269 |
RKI-1447
|
RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2. |
| DC8831 |
RKI-1313
|
RKI-1313 is the negative control for RKI-1447 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer |
| DC7774 |
Ripasudil(K-115)
|
K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension. |
| DC9614 |
Hydroxyfasudil (hydrochloride)
|
Hydroxyfasudil Hcl(HA1100 Hcl), metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.
|
| DC7144 |
GSK429286A
|
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. |
