RO5126766(CH5126766)

Cas No.:	946128-88-7
Chemical Name:	3-​[[2-​[(Methylaminosulfony​l)​amino]​-​3-​fluoropyridin-​4-​yl]​methyl]​-​4-​methyl-​7-​[(pyrimidin-​2-​yl)​oxy]​-​2H-​1-​benzopyran-​2-​one SMILES: O=C1C(CC2=C(F)C(NS(=O)(NC)=O)=NC=C2)=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3O1
Synonyms:	RO5126766; RO 5126766; RO-5126766; CH5126766; CH-5126766; CH 5126766.
SMILES:	CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F
Formula:	C21H18FN5O5S
M.Wt:	471.46152
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific For the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of of target gene transcription that promotes malignant trans Formation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis.For the detailed information of ro5126766, the solubility of ro5126766 in water, the solubility of ro5126766 in DMSO, the solubility of ro5126766 in PBS buffer, the animal experiment (test) of ro5126766, the cell expriment (test) of ro5126766, the in vivo, in vitro and clinical trial test of ro5126766, the EC50, IC50,and Affinity of ro5126766, Please contact DC Chemicals.