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| Cas No.: | 1333714-43-4 |
| Chemical Name: | (Rac)-Benpyrine |
| SMILES: | O=C1N(CC2=CC=CC=C2)CC(NC3=C4N=CNC4=NC=N3)C1 |
| Formula: | C16H16N6O |
| M.Wt: | 308.34 |
| Purity: | >98% |
| Sotrage: | 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Description: | (Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. |
| Target: | TNF-α |
| In Vivo: | (Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1]. Animal Model: Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1] Dosage: 25 mg/kg, 50 mg/kg Administration: Oral gavage; daily; for 3 weeks Result: The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased. |
| In Vitro: | (Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1]. |
| References: | [1]. Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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