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(S)-Verapamil hydrochloride

  Cat. No.:  DC28814   Featured
Chemical Structure
36622-28-3
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Field of application
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 36622-28-3
Chemical Name: S(-)-VERAPAMIL
Synonyms: S(-)-VERAPAMIL;(S)-(-)-Verapamil Hydrochloride;(S)-(-)-Verapamil Hy;S(-)-VERAPAMIL HCL;S(−)-Verapamil hydrochloride hydrate;(S)-Verapamil hydrochloride
SMILES: [Cl-].COC1C(OC)=CC(CCC([N+])CCC[C@@](C#N)(CC)C2C=C(OC)C(OC)=CC=2)=CC=1
Formula: C26H37N2O4+.Cl-
M.Wt: 477.03598
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].
Target: LTC4 Ca2+
In Vitro: (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].
References: [1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.
MSDS
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Cat. No. Product name Field of application
DC71156 SR2640 hydrochloride SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma.
DC40870 Etalocib Etalocib (LY293111), an orally active leukotriene B4 receptor antagonist, inhibits the binding of [3H]LTB4, with a Ki of 25 nM. Etalocib (LY293111) prevents LTB4-induced calcium mobilization with an lC50 of 20 nM. Etalocib (LY293111) induces apoptosis.
DC28814 (S)-Verapamil hydrochloride (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.
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