| Cas No.: | 36622-28-3 |
| Chemical Name: | S(-)-VERAPAMIL |
| Synonyms: | S(-)-VERAPAMIL;(S)-(-)-Verapamil Hydrochloride;(S)-(-)-Verapamil Hy;S(-)-VERAPAMIL HCL;S(−)-Verapamil hydrochloride hydrate;(S)-Verapamil hydrochloride |
| SMILES: | [Cl-].COC1C(OC)=CC(CCC([N+])CCC[C@@](C#N)(CC)C2C=C(OC)C(OC)=CC=2)=CC=1 |
| Formula: | C26H37N2O4+.Cl- |
| M.Wt: | 477.03598 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1]. |
| Target: | LTC4 Ca2+ |
| In Vitro: | (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1]. |
| References: | [1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309. |
MSDS
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| MSDS_12866_DC28814_36622-28-3 |
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