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SCH58261

  Cat. No.:  DC9284   Featured
Chemical Structure
160098-96-4
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More than 5000 active chemicals with high quality for research!
Field of application
SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a. SCH58261 could enhance the transfection efficiency to 2-fold to 5-fold of Lipofectamine 3000 and LNP, all of which are currently approved for clinical use in the treatment of the most common malignant tumors.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 160098-96-4
Chemical Name: SCH-58261,SCH 58261
Synonyms: SCH-58261,SCH 58261
SMILES: C1=CC=C(C=C1)CCN2C3=C(C=N2)C4=NC(=NN4C(=N3)N)C5=CC=CO5
Formula: C18H15N7O
M.Wt: 345.36
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Improving lipid nanoparticles delivery efficiency of macrophage cells by using immunomodulatory small molecules-Lirong Yi PhD , Ziyan Zhang MSc-Nanomedicine: Nanotechnology, Biology and Medicine Volume 64, February 2025, 102809
Description: SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a. SCH58261 could enhance the transfection efficiency to 2-fold to 5-fold of Lipofectamine 3000 and LNP, all of which are currently approved for clinical use in the treatment of the most common malignant tumors.
In Vivo: it was demonstrated that the selective antagonist of the A2Areceptor, SCH58261, administered i.p. starting from the early minutes after ischemia induction, reduces ischemic brain damage and neurological deficit 24 h thereafter. vehicle-rats received saline with Tween 80 (1 %) administered (i.p.) .SCH58261 (0.01 mg/kg, i.p.), administered twice/day for 7 days [2]
In Vitro: NK cells were cultured in NK cell media and preincubated with or without 1 uM SCH58261 30 min before simulation with indicated concentrations of IL-18 (R & D Systems) and IL-12p70 (Australian Biosearch) in the presence or absence of NECA (1 uM) or CGS-21680 (100 nM).[1]
References: Improving lipid nanoparticles delivery efficiency of macrophage cells by using immunomodulatory small molecules-Lirong Yi PhD , Ziyan Zhang MSc-Nanomedicine: Nanotechnology, Biology and Medicine Volume 64, February 2025, 102809
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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