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SIRT1-IN-1

  Cat. No.:  DC40849  
Chemical Structure
352554-02-0
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More than 5000 active chemicals with high quality for research!
Field of application
SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 352554-02-0
Chemical Name: SIRT1-IN-1
SMILES: O=C(C1C(NC2=C3C=C(C)C=C2)=C3CCC1)N
Formula: C14H16N2O
M.Wt: 228.29
Sotrage: Powder-20°C3 years4°C2 yearsIn solvent-80°C 6 months-20°C1 month
MSDS
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MSDS_23862_DC40849_352554-02-0
COA
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Cat. No. Product name Field of application
DC47336 JGB1741 JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research.
DC47335 ADTL-SA1215 ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer.
DC47334 Ainsliadimer C Ainsliadimer C, a potential activator of SIRT1, ameliorates inflammatory responses in adipose tissue.
DC46692 NRD167 NRD167 is a potent and selective SIRT5 inhibitor.
DC45335 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol, a SIRT1 activator, exhibits significant stimulation of SIRT1 activity. Anti-tumor activity.
DC45272 7-Chloro-4-(piperazin-1-yl)quinoline 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively.
DC45271 SRT3657 SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect.
DC45270 CHIC35 CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 µM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 µM) or SIRT3 (IC50>100 µM). CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research.
DC40849 SIRT1-IN-1 SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity.
DC40750 SIRT-IN-3 SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively).
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