Cas No.: | 823218-99-1 |
Synonyms: | SN2;SN-2 |
SMILES: | CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4 |
Formula: | C17H21NO |
M.Wt: | 255.3547 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | SN 2 is a novel and potent small molecule activator of TRPML3 with EC50 of 1.13 uM. Compounds SF21, SF-41, and SN-2 elicited a much more rapid increase than the other compounds, with SF-33 and SF 51 displaying the slowest kinetics. SN-2 had a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at -80 mV. |