SPP1

  Cat. No.:  DC12551  
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
Spiropiperidine 1 (SPP1)i s a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.
Cas No.:
Chemical Name: cyclopropyl 4-(3-methyl-4-oxo-1-(m-tolyl)-1,3,8-triazaspiro[4.5]decan-8-yl)piperidine-1-carboxylate
Synonyms: Spiropiperidine 1|SPP1
Formula: C24H34N4O3
M.Wt: 426.561
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Spiropiperidine 1 (SPP1)i s a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors; stimulates Gq mediated GTPγ[35S] signaling with IC50 of 12.3 nM, stimulates Gq mediated signaling in membranes prepared from rat cortex with EC50 of 21 nM; displays high functional selectivity for M1 receptors over native M2 and M3 receptor anti-targets and over a panel of other targets.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC47243 Dehydroglyasperin C Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
DC47227 (−)-Myrtenal (−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.
DC47224 GPX4-IN-3 GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
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DC47140 Yadanzioside K Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
DC47105 Complanatoside B Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects.
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