SPR-00305|SPR00305|SPR 00305

Cas No.:	1965261-97-5
Chemical Name:	7-chloro-3-(2-(6-cyclopropyl-1H-indol-3-yl)-2-oxoethoxy)-2-naphthamide
Synonyms:	SPR-00305 potently inhibited the MvfR pathway with IC50s of 115 nM against 4-hydroxy-2-heptylquinoline (HHQ), 93 nM against pyocyanin (PYO) and 109 nM against 3,4-dihydroxy-2-heptoquinoline (PQS) in PA14.
SMILES:	C1=C2C(C=CC(Cl)=C2)=CC(OCC(C2C3=C(NC=2)C=C(C2CC2)C=C3)=O)=C1C(N)=O
Formula:	C₂₄H₁₉ClN₂O₃
M.Wt:	418.877
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SPR-00305 is a potent MvfR inhibitor and displays target engagement. SPR-00305, potently inhibited the MvfR pathway with IC50s of 115 nM against 4-hydroxy-2-heptylquinoline (HHQ), 93 nM against pyocyanin (PYO) and 109 nM against 3,4-dihydroxy-2-heptoquinoline (PQS) in PA14. The compound was further tested in the immunocompetent acute thigh infection model. It decreased PQS by 50% and HHQ by 40% in comparison with vehicle. In the neutropenic acute thigh infection model, SPR-00305 oral administration (200 mg) resulted in a slight decrease in HHQ levels.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47250	Nonanal	Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
DC47249	Piperitone	Piperitone is as a powerful repellent and antiappetent agent. Piperitone is very toxic to Cymbopogon schoenanthus (C. schoenanthus) adults, newly laid eggs and to neonate larvae. Insecticidal activity.
DC47247	Tyrosylleucine TFA	Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47243	Dehydroglyasperin C	Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
DC47227	(−)-Myrtenal	(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.
DC47224	GPX4-IN-3	GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
DC47179	Tyrosylleucine	Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47178	Mead acid	Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency.
DC47140	Yadanzioside K	Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
DC47105	Complanatoside B	Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects.