| DC70802 |
SS-208
|
SS-208 (SS208) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 12 nM, >100-fold selectivity over HDAC1/4/5/7/8/9/11.SS-208 has minimal effects on the viability of murine SM1 melanoma cells in vitro, significantly reduced in vivo tumor growth in a murine SM1 syngeneic melanoma mouse model. |
| DC3110 |
CUDC-907 (PI3K/HDAC InhibitorI)
|
CUDC-907 (PI3K/HDAC Inhibitor I) is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively. |
| DC8252 |
Vorinostat (SAHA)
|
Vorinostat (SAHA) is an HDAC1/3 inhibitor with IC50 of ~10 nM. |
| DC8663 |
UF010
|
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs. |
| DC6303 |
Tubastatin A HCl
|
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). |
| DC6304 |
Tubastatin A
|
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). |
| DC5178 |
Tubacin (BML-GR362)
|
Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2). |
| DC8134 |
Trichostatin A (TSA)
|
Trichostatin A (TSA) is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM; HDAC8 is the only known member of the HDAC-family that is not affected by TSA. |
| DC7716 |
TMP269
|
TMP269 is a novel and selective class IIa histone deacetylase inhibitor with IC50s of 126/80/36/9 nM for HDAC 4/5/7/9, respectively; 20-400 fold selectivity over class1 HDACs. |
| DC10210 |
TMP195
|
TMP195 is the most potent and selective class IIa HDAC inhibitor. |
