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SW-100

  Cat. No.:  DC12634   Featured
Chemical Structure
2126744-35-0
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More than 5000 active chemicals with high quality for research!
Field of application
SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM, displays >1,000-fold selectivity over all other class I, II, and IV HDAC isoforms.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2126744-35-0
Chemical Name: 4-[(6-Chloro-3,4-dihydro-2H-quinolin-1-yl)methyl]-N-hydroxybenzamide
Synonyms: 4-[(6-Chloro-3,4-dihydro-2H-quinolin-1-yl)methyl]-N-hydroxybenzamide
SMILES: ClC1C([H])=C([H])C2=C(C=1[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C1C([H])=C([H])C(C(N([H])O[H])=O)=C([H])C=1[H]
Formula: C17H17ClN2O2
M.Wt: 316.782083272934
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier[1].
Target: HDAC1:5.23 μM (IC50) HDAC2:32.8 μM (IC50) HDAC3:29.5 μM (IC50) HDAC4:10.9 μM (IC50) HDAC5:4.07 μM (IC50) HDAC6:2.3 nM (IC50) HDAC7:4.55 μM (IC50) HDAC8:3.72 μM (IC50) HDAC9:3.46 μM (IC50) HDAC10:26.2 μM (IC50) HDAC11:5.72 μM (IC50)
In Vivo: SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome[1]. Animal Model: 8-10 weeks old C57BL/6 mice (Fmr1-/- mice)[1] Dosage: 20 mg/kg Administration: Intraperitoneal injection; twice a day for two days Result: Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1-/- mice。
In Vitro: SW-100 (0.01-10 µM; 48 hours) shows obvious increase in the acetylated α-tubulin levels in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: HEK293 cells Concentration: 0.01, 0.1, 1, 10 µM Incubation Time: 48 hours Result: Showed obvious increase in the acetylated α-tubulin levels in a dose-dependent manner.
References: [1]. Kozikowski AP, et al. Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and LearningImpairments in a Mouse Model of Fragile X Syndrome. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695.
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2018-0101
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2018-0101
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