T0901317
Cat. No.: DC9842
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Chemical Structure
293754-55-9
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Field of application
T0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively).
| Cas No.: |
293754-55-9 |
| Chemical Name: |
Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- |
| Synonyms: |
T0901317,T 0901317,T-0901317 |
| SMILES: |
C(S(N(CC(F)(F)F)C1=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C1)(=O)=O)1=CC=CC=C1 |
| Formula: |
C17H12F9NO3S |
| M.Wt: |
481.33 |
| Purity: |
>98% |
| Sotrage: |
4°C for 1 year, -20°C for more than 2 years |
| Description: |
T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively. |
| References: |
[1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96
[2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5 |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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