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TAS-301

  Cat. No.:  DC8376   Featured
Chemical Structure
193620-69-8
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More than 5000 active chemicals with high quality for research!
Field of application
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 193620-69-8
Chemical Name: 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
Synonyms: TAS-301,TAS 301.TAS301
SMILES: N1C2=C(C=CC=C2)/C(=C(\C2=CC=C(OC)C=C2)/C2=CC=C(OC)C=C2)/C1=O
Formula: C23H19NO3
M.Wt: 357.4
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits PKC activation induced by PDGF.
In Vivo: TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury[2].
In Vitro: TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively[1]. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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