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| Cas No.: | 193620-69-8 |
| Chemical Name: | 3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | TAS-301,TAS 301.TAS301 |
| SMILES: | N1C2=C(C=CC=C2)/C(=C(\C2=CC=C(OC)C=C2)/C2=CC=C(OC)C=C2)/C1=O |
| Formula: | C23H19NO3 |
| M.Wt: | 357.4 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits PKC activation induced by PDGF. |
| In Vivo: | TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury[2]. |
| In Vitro: | TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively[1]. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM[2]. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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