TBA-354|TBA354|DC Chemicals

Cas No.:	1257426-19-9
Synonyms:	TBA 354 ，TBA354
SMILES:	FC(F)(F)OC1=CC=C(C2=CC=C(CO[C@H]3CN4C(OC3)=NC([N+]([O-])=O)=C4)C=N2)C=C1
Formula:	C₁₉H₁₅F₃N₄O₅
M.Wt:	436.34
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates . TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy For the detailed information of TBA-354 , the solubility of TBA-354 in water, the solubility of TBA-354 in DMSO, the solubility of TBA-354 in PBS buffer, the animal experiment (test) of TBA-354 , the cell expriment (test) of TBA-354 , the in vivo, in vitro and clinical trial test of TBA-354 , the EC50, IC50,and affinity,of TBA-354 , Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC8115	Vancomycin hydrochloride	Vancomycin hydrochloride in stock,price: 500 USD/100mg. 0
DC7940	TBA-354	TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.
DCAPI1325	Rifabutin (Mycobutin)	Rifabutin (Mycobutin)
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DC10307	Framycetin	Framycetin (Fradiomycin B; Neomycin B) is an aminoglycoside antibiotic. It inhibits hammerhead ribozyme with a Ki of 13.5 μM.
DC8937	Clarithromycin	Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.