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| Cas No.: | 1257426-19-9 |
| Synonyms: | TBA 354 ，TBA354 |
| SMILES: | FC(F)(F)OC1=CC=C(C2=CC=C(CO[C@H]3CN4C(OC3)=NC([N+]([O-])=O)=C4)C=N2)C=C1 |
| Formula: | C19H15F3N4O5 |
| M.Wt: | 436.34 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates . TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy For the detailed information of TBA-354 , the solubility of TBA-354 in water, the solubility of TBA-354 in DMSO, the solubility of TBA-354 in PBS buffer, the animal experiment (test) of TBA-354 , the cell expriment (test) of TBA-354 , the in vivo, in vitro and clinical trial test of TBA-354 , the EC50, IC50,and affinity,of TBA-354 , Please contact DC Chemicals. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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