Cas No.: | 1011244-68-0 |
Chemical Name: | N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide |
SMILES: | C1=CC(=CC=C1C(=O)NC2=NC=C(C=C2)N)C(F)(F)F |
Formula: | C13H10F3N3O |
M.Wt: | 281.23 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM. |
Target: | COX-1:0.8 μM (IC50) Human Endogenous Metabolite |
In Vitro: | TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM, while that against COX-2 is over 200 μM. |
References: | [1]. Kakuta H, et al. Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1840-3. |