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TUG891

  Cat. No.:  DC9981   Featured
Chemical Structure
1374516-07-0
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More than 5000 active chemicals with high quality for research!
Field of application
TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1374516-07-0
Chemical Name: TUG-891
Synonyms: TUG 891;3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic a cid;TUG-891;3-(4-((2-(cyanomethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid;3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid;CHEMBL2386353;KB-145939;QC-4555;TUG-770;3-(4-((4-Fluoro-4-methyl-[1,1-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid;4-[(4-Fluoro-4′-methyl[1,1′-biphenyl]-2-yl)methoxy]-benzenepropanoic acid;TUG891;3-(4-{[5-fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid;3-(4-((4-Fluoro-4-methyl-[1,1-biphenyl]-2-yl)methoxy)phenyl)propanoic acid;4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid;3-[4-[[5-fluoro-2-(4-methylphenyl)phenyl]methoxy]phenyl]propanoic acid;3-(4-((4-fluoro-4'-methylbiphenyl-2-yl)methoxy)phenyl)propanoic acid;3-{4-[(4-fluoro-4'-methylbiphenyl-2-yl)methoxy]phenyl}propanoic acid;GTPL6490;3-(4-((4-Fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid;10.1021/jm300215x;K 201 |;KG-0018;Not available;TUG 891|TUG891;YN9;AMY10839;CHEMBL2058533;Q27089037;C72503;AC-36080;EX-A1220;AKOS016340424;3-[4-({4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl}methoxy)phenyl]propanoic acid;3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid;GLXC-04922;1374516-07-0;GPU-028;HY-100881;BDBM50420167;ZEC51607;CS-6138;A920732;MFCD22421654;s6775;SCHEMBL15264542;BCP19294
SMILES: C1C(C2C=CC(C)=CC=2)=C(COC2C=CC(CCC(=O)O)=CC=2)C=C(F)C=1
Formula: C23H21FO3
M.Wt: 364.409450292587
Purity: >98%
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4.
In Vitro: TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC9981 TUG891 TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively.
DC5073 TAK-875(Fasiglifam) TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM.
DC8577 FFA4 (GPR120) agonist GSK137647A GSK-137647 is a potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3.
DC8593 GPR120 Compound A GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1).
DC10554 DC260126 DC260126, a small-molecule antagonist of GPR40.
DC7867 AMG-837 AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
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