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Talampanel (GYKI 53773)

  Cat. No.:  DC7863   Featured
Chemical Structure
161832-65-1
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More than 5000 active chemicals with high quality for research!
Field of application
Talampanel is a novel anticonvulsant that acts as an allosteric inhibitor of the AMPA receptor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 161832-65-1
Chemical Name: 1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
Synonyms: Ampanel, Kinampa, Talampanel (INN), GYKI 53773, AC1L4UWP, AC1Q5KPR
SMILES: C[C@@H]1CC2=C(C=C3OCOC3=C2)C(C4=CC=C(N)C=C4)=NN1C(C)=O
Formula: C19H19N3O3
M.Wt: 337.372
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED).
In Vivo: Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2]
In Vitro: Talampanel is a glutamate receptor inhibitor with anti-seizure activity.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC8824 Traxoprodil Traxoprodil is an NMDA ε 2 (NR2B) antagonist that has been studied as an alternative to serotonin selective reuptake inhibitors.
DC7863 Talampanel (GYKI 53773) Talampanel is a novel anticonvulsant that acts as an allosteric inhibitor of the AMPA receptor.
DC8175 Rapastinel(GLYX-13) Rapastinel(GLYX-13) is a NMDA receptor partial agonist that acts at the glycine site.
DC8307 QNZ46 QNZ is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively).
DC7226 Perampanel(E2007） Perampanel(E2007; ER 155055-90) is a selective noncompetitive AMPA-type glutamate receptor antagonist which has demonstrated anticonvulsant activity in experimental seizure models and antiepileptic activity in clinical trials.
DC7989 PEPA PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
DC11382 NYX-2925 NYX-2925 is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory.
DC7576 NVP-AAM077 NVP-AAM077 is a potent antagonist for NMDA receptors.
DC11406 NBQX NBQX is a potent aminomethylphosphonic acid receptor (AMPAR) antagonist with an IC50 of 0.7 ± 0.1 μM.
DC7194 MDL 29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation (Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo.
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