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Home > Inhibitors & Agonists > Ras-Raf-MAPK-ERK > MEK (MAP2K)

Vacquinol-1

  Cat. No.:  DC8473   Featured
Chemical Structure
5428-80-8
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More than 5000 active chemicals with high quality for research!
Field of application
Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 5428-80-8
Chemical Name: 2-(4-chlorophenyl)-α-2-piperidinyl-4-quinolinemethanol
Synonyms: NSC 13316,NSC13316,NSC-13316,Vacquinol 1,Vacquinol1
SMILES: ClC1C=CC(C2C=C(C(C3CCCCN3)O)C3C=CC=CC=3N=2)=CC=1
Formula: C21H21ClN2O
M.Wt: 352.9
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC7488 RO4987655 RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.
DC8473 Vacquinol-1 Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.
DC7243 U0126 U0126-EtOH(U-0126) is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059.
DC1099 Trametinib Trametinib is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.
DC7308 TAK-733 TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc.
DC7808 Refametinib (BAY86-9766) Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
DC1056 PD0325901 (Mirdametinib) PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
DC5100 PD 98059 PD 98059 is a selective inhibitor of MEK and blocker of MAPK
DC7723 OTS964， OTS 964 OTS964 is a novel TOPK(T–lymphokine-activated killer cell–originated protein kinase) inhibitor.
DC4177 Cobimetinib(GDC-0973; XL518) GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase, also known as MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway.
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