WHI-P180(Janex 3)

  Cat. No.:  DC8068   Featured
Chemical Structure
211555-08-7
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More than 5000 active chemicals with high quality for research!
Field of application
WHI-P180(Janex 3) is a potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (CDK2; IC50 = 1µM) by blocking the ATP site
Cas No.: 211555-08-7
Chemical Name: 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
Synonyms: WHI P180,Janex3,WHIP180,Janex-3
SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)O)OC
Formula: C16H15N3O3
M.Wt: 297.31
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibits RET, KDR and EGFR with IC50s of 5 nM, 66 nM and 4 μM, respectively.
In Vivo: WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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