WYE125132|cas 1144068-46-1|supplier DC Chemicals

Cas No.:	1144068-46-1
Chemical Name:	N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
Synonyms:	WYE-125132,WYE 125132
SMILES:	O=C(NC1=CC=C(C2=NC(N3CC4CCC(C3)O4)=C5C(N(N=C5)C6CCC7(CC6)OCCO7)=N2)C=C1)NC
Formula:	C₂₇H₃₃N₇O₄
M.Wt:	519.6
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus.For the detailed information of WYE125132, the solubility of WYE125132 in water, the solubility of WYE125132 in DMSO, the solubility of WYE125132 in PBS buffer, the animal experiment (test) of WYE125132, the cell expriment (test) of WYE125132, the in vivo, in vitro and clinical trial test of WYE125132, the EC50, IC50,and Affinity of WYE125132, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47560	(32-Carbonyl)-RMC-5552	(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2).
DC47559	Dihydroevocarpine	Dihydroevocarpine induces cytotoxicity in acute myeloid leukemia via suppressing the mTORC1/2 activity.
DC47252	RMC-6272	RMC-6272 (RM-006) is a bi-steric mTORC1-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors.
DC44210	mTOR inhibitor-8	mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.
DC5088	WYE125132	WYE125132 is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor
DC3101	Ku-0063794	KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM.
DC11150	ICSN3250	ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
DC11151	ICSN3250 hydrochloride	ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.