YK-009|Ionizable Lipid for LNP

Cas No.:	2761458-86-8
Chemical Name:	2-Octyldecyl 6-[[4-(decyloxy)-4-oxobutyl](2- hydroxyethyl)amino]hexanoate
Synonyms:	YK009, YK 009
SMILES:	CCCCCCCCCCOC(=O)CCCN(CCO)CCCCCC(=O)OCC(CCCCCCCC)CCCCCCCC
Formula:	C₄₀H₇₉NO₅
M.Wt:	654.06
Purity:	>95%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Long, J., Yu, C., Zhang, H., et al. Novel ionizable lipid nanoparticles for SARS-CoV-2 omicron mRNA delivery. Adv. Healthc. Mater. 12(13), 2202590 (2023).

Cat. No.	Product name	Field of application
DC85555	YK-009	YK-009 is an advanced, biodegradable ionizable lipid designed for efficient mRNA delivery. Via intramuscular injection, it demonstrates superior targeting to draining lymph nodes, boosting immune cell transfection for vaccines. When administered intravenously, it distributes to the liver but leverages a highly degradable chemical backbone to ensure rapid clearance post-endosomal escape. This effectively eliminates the risk of long-term tissue accumulation and liver toxicity seen in traditional lipids. Delivering a balance of high transfection efficiency and exceptional biocompatibility, YK-009 is an ideal component for safe and potent lipid nanoparticle (LNP) formulations.