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Ac-YVAD-cmk

  Cat. No.:  DC48112   Featured
Chemical Structure
178603-78-6
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More than 5000 active chemicals with high quality for research!
Field of application
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 178603-78-6
Chemical Name: L-Alaninamide,N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
Synonyms: Ac-Tyr-Val-Ala-Asp-chloromethylketone;Ac-Tyr-Val-Ala-Asp-CMK;AC-YVAD-CMK;L-Alaninamide,N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-;N-Ac-Tyr-Val-Ala-Asp-CMK;AC-TYR-ALA-ASP-CHLOROMETHYLKETONE;AC-TYR-VAL-ALA-ASP-CH2CL;AC-YVAD-CHLOROMETHYLKETONE;AC-YVKD-CMK;ICE INHIBITOR II;IL-1BETA CONVERTING ENZYME INHIBITOR II;PASE-1 INHIBITOR II;N-Acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-alaninamide;N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone;CASPASE-1 INHIBITOR II
SMILES: CC([C@H](NC([C@@H](NC(C)=O)CC1=CC=C(O)C=C1)=O)C(N[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)C)=O)C
Formula: C24H33ClN4O8
M.Wt: 540.99400
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_32003_DC48112_178603-78-6
COA
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Cat. No. Product name Field of application
DC48112 Ac-YVAD-cmk Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.
DC45548 Boc-Asp(OMe)-fluoromethyl ketone Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
DC5080 Belnacasan (VX-765) VX-765 is a novel Caspase-1 inhibitor with an IC 50 of 0.8nM being investigated for the treatment of epilepsy, currently being developed by Vertex.
DC9283 Q-VD-Oph Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9.
DC9762 Emricasan Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor.
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