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AMG2008827

Cat. No.: DC74466

Chemical Structure

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Field of application

A potent, selective γ-secretase inhibitor that significantly reduces the right ventricular systolic pressure and right heart hypertrophy in hypoxia/SU5416 (SUHx) rats..

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:
Chemical Name:	AMG2008827

MSDS

Cat. No.	Product name	Field of application
DC47093	Fosciclopirox	Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.
DC7496	Semagacestat	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM.
DC74466	AMG2008827	A potent, selective γ-secretase inhibitor that significantly reduces the right ventricular systolic pressure and right heart hypertrophy in hypoxia/SU5416 (SUHx) rats..
DC48366	γ-Secretase modulator 10	γ-Secretase modulator 10 is a novel γ-secretase modulator.

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