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Chiauranib

  Cat. No.:  DC72116   Featured
Chemical Structure
1256349-48-0
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More than 5000 active chemicals with high quality for research!
Field of application
Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1256349-48-0
Chemical Name: Chiauranib
Synonyms: CS 2164;Chiauranib;N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide;F40IRN5981;CS2164;N-(2-aminophenyl)-6-(7-methoxyquinolin-4-yl)oxynaphthalene-1-carboxamide;chiauranib (pseudo INN);GTPL10475;example 32 [US20100298358A1];E77807;N-(2-aminophenyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide;N-(2-Aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide;EX-A6106;EX-A6106;EX-A6106;EX-A6106;EX-A6106;EX-A6106;CHIAURANIB [WHO-DD];CHIAURANIB [WHO-DD];CHIAURANIB [WHO-DD];CHIAURANIB [WHO-DD];CHIAURANIB [WHO-DD];CHIAURANIB [WHO-DD];CHIAURANIB [WHO-DD];BRKWREZNORONDU-UHFFFAOYSA-N;BRKWREZNORONDU-UHFFFAOYSA-N;BRKWREZNORONDU-UHFFFAOYSA-N;BRKWREZNORONDU-UHFFFAOYSA-N;BRKWREZNORONDU-UHFFFAOYSA-N;BRKWREZNORONDU-UHFFFAOYSA-N;BRKWREZNORONDU-UHFFFAOYSA-N;ibcasertib [INN];ibcasertib [INN];ibcasertib [INN];ibcasertib [INN];ibcasertib [INN];ibcasertib [INN];ibcasertib [INN];AKOS040754703;AKOS040754703;AKOS040754703;AKOS040754703;AKOS040754703;AKOS040754703;AKOS040754703;AS-84740;AS-84740;AS-84740;AS-84740;AS-84740;AS-84740;AS-84740;UNII-F40IRN5981;UNII-F40IRN5981;UNII-F40IRN5981;UNII-F40IRN5981;UNII-F40IRN5981;UNII-F40IRN5981;UNII-F40IRN5981;HY-124526;HY-124526;HY-124526;HY-124526;HY-124526;HY-124526;HY-124526;ibcasertib;ibcasertib;ibcasertib;ibcasertib;ibcasertib;ibcasertib;ibcasertib;N-(2-aminophenyl)-6-[(7-methoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide;N-(2-aminophenyl)-6-[(7-methoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide;N-(2-aminophenyl)-6-[(7-methoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide;N-(2-aminophenyl)-6-[(7-methoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide;N-(2-aminophenyl)-6-[(7-methoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide;N-(2-aminophenyl)-6-[(7-methoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide;SCHEMBL3757428;SCHEMBL3757428;SCHEMBL3757428;SCHEMBL3757428;SCHEMBL3757428;N-(2-aminophenyl)-6-[(7-methoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide;SCHEMBL3757428;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;SCHEMBL3757428;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;CHEMBL5095033;CHEMBL5095033;CHEMBL5095033;CHEMBL5095033;1-Naphthalenecarboxamide, N-(2-aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-;CHEMBL5095033;CHEMBL5095033;1256349-48-0;1256349-48-0;1256349-48-0;1256349-48-0;CHEMBL5095033;1256349-48-0;1256349-48-0;CS-2164;CS-2164;CS-2164;CS-2164;1256349-48-0;CS-2164;CS-2164;CS-0086815;CS-0086815;CS-0086815;CS-0086815;CS-2164;CS-0086815;CS-0086815;CS-0086815
SMILES: O(C1C([H])=C([H])N=C2C([H])=C(C([H])=C([H])C=12)OC([H])([H])[H])C1C([H])=C([H])C2C(C(N([H])C3=C([H])C([H])=C([H])C([H])=C3N([H])[H])=O)=C([H])C([H])=C([H])C=2C=1[H]
Formula: C27H21N3O3
M.Wt: 435.4739
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC72116 Chiauranib Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
DC46183 TPX-0022(CSF1R-IN-2) TPX-0022 (CSF1R-IN-2) is a potent inhibitor of MET/CSF1R/SRC with enzymatic kinase inhibition IC50s of 0.14 nM, 0.71 nM and 0.12 nM, respectively. TPX-0022 modulates the tumor immune microenvironment in preclinical models.
DC40860 DCC-3014(Vimseltinib) DCC-3014(Vimseltinib) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively.
DC12490 AZD7507 AZD7507 (AZD-7507) is a potent, selective, orally available CSF-1R (c-FMS) with IC50 of 32 nM.
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