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CHMFL-PI4K-127

  Cat. No.:  DC71906   Featured
Chemical Structure
2377604-81-2
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Field of application
CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC50 of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2377604-81-2
Chemical Name: CHMFL-PI4K-127
Synonyms: [3,3'-Bipyridine]-5-carboxamide, 6'-chloro-N-methyl-5'-[(phenylsulfonyl)amino]-;CHMFL-PI4K-127
SMILES: C1=NC=C(C(NC)=O)C=C1C1=CC(NS(C2=CC=CC=C2)(=O)=O)=C(Cl)N=C1
Formula: C18H15ClN4O3S
M.Wt: 402.854701280594
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_36208_DC71906_2377604-81-2
COA
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Cat. No. Product name Field of application
DC71906 CHMFL-PI4K-127 CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC50 of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy.
DC8254 PIK-93 PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.
DC10061 PI4KA inhibitor-A1 GSK-A1 is a potent inhibitor of PI4KA. In vitro using HEK-AT1 cells, GSK-A1 had an IC50 of about 3 nM.
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