CPAG-1|CAS 2094991-62-3|DC Chemicals

Cas No.:	2094991-62-3
Chemical Name:	CPAG-1
Formula:	C₂₀H₂₆N₂O₂
M.Wt:	326.44
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Andrea Galmozzi, et al. Nature. 2019 Dec;576(7785):138-142. 2. Christopher G Parker, et al. Cell. 2017 Jan 26;168(3):527-541.e29.

Description:	CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2. CPAG-1 treatment had no effect on weight or food intake but treated mice had reduced fasting glycemia and insulin levels. CPAG-1 decreased Rev-Erbα protein in BAT of CPAG-1-treated mice. CPAG-1 also significantly increased labile heme in the nucleus of brown adipocytes from CPAG-1-treated mice within 4 days of treatment.
References:	1. Andrea Galmozzi, et al. Nature. 2019 Dec;576(7785):138-142. 2. Christopher G Parker, et al. Cell. 2017 Jan 26;168(3):527-541.e29.

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