Darizmetinib|CAS 2369583-33-3|DC Chemicals

Cas No.:	2369583-33-3
Chemical Name:	Darizmetinib
Synonyms:	Q2HX6A3UDW;darizmetinib [INN];N-{2,6-Difluoro-3-[5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide;CHEMBL4795907;N-[2,6-Difluoro-3-[[5-(4-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]carbonyl]phenyl]-1-propanesulfonamide;CS-0641170;2369583-33-3;N-{2,6-difluoro-3-[5-(pyridin-4-yl)-1H-pyrazolo[3,4- b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide;example 63 [WO2019149738A1];N-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamide;Darizmetinib;SCHEMBL21223057;HY-152860;1-Propanesulfonamide, N-[2,6-difluoro-3-[[5-(4-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]carbonyl]phenyl]-;GLXC-26811;GTPL12376
SMILES:	S(CCC)(NC1C(=CC=C(C(C2=C3C=C(C=NC3=NN2)C2C=CN=CC=2)=O)C=1F)F)(=O)=O
Formula:	C₂₁H₁₇F₂N₅O₃S
M.Wt:	457.453189611435

MSDS

Cat. No.	Product name	Field of application
DC74341	NFX-179	NFX-179 (Nedometinib, NFX179) is a potent, specific, topical, metabolically labile MEK1/2 inhibitor with biochemical IC50 of 135 nM (MEK1).
DC74339	HRX-0233	HRX-0233 (HRX0233) is a potent and selective inhibitor of MAP2K4 (MKK4), a kinase involved in the stress-activated protein kinase (SAPK) signaling pathway. MAP2K4 plays a role in regulating cellular responses to stress, apoptosis, and tumorigenesis. HRX-0233 has shown particular promise in KRAS-mutant cancers, where it exhibits synergistic effects with RAS inhibitors, making it a potential candidate for combination therapy in these difficult-to-treat cancers.
DC74336	Darizmetinib	Darizmetinib (HRX-0215, HRX0215) is a potent, selective inhibitor of MKK4 (MAP2K4/SEK1), shows potential for promoting liver regeneration or reducing or preventing hepatocyte death.
DC70510	INR119	INR119 is a small molecule allosteric MAPKK (MAP2K, MEK1/2) inhibitor, binds fission yeast homologue Wis1 near C458 and protects Wis1 from inactivation by low levels of H2O2 in vitro.INR119 pretreatment strongly potentiates the Wis1 response to low H2O2 in vivo.Phosphorylation of Sty1 depends entirely on activated Wis1, and the INR119-induced enhancement of Sty1 pathway activation upon H2O2 stress requires the upstream activation of Wis1 through the MAPKKKs.
DC7868	AS703026（Pimasertib）	AS703026(Pimasertib) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines.
DC8744	PD318088	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
DC7077	AZD8330(ARRY-424704; ARRY-704)	AZD8330(ARRY-424704; ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM.
DC11959	PD 184161	A potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.