DEBIO 1143|CAS 1071992-99-8|DC Chemicals

Cas No.:	1071992-99-8
Chemical Name:	AT-406
Synonyms:	(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-cArboxamide;(5S,8S,10aR)-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide;AT406 (SM-406);SM 406;QCR-136;(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo[1,2-a][1,5]diazocine-8-carboxamide;AT406;AT 406;N65WC8PXDD;(5S,8S,10aR)-N-(Diphenylmethyl)-5-[(N-methyl-L-alanyl)amino]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide;(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-(((2S)-2-(methylamino)-1-oxopropyl)amino)-3;Debio 1143;GTPL7729;SM406;Xevinapant;UNII-N65WC8PXDD;MSC2735845A;XEVINAPANT [USAN];NCGC00346675-01;BDBM50393505;s2754;XEVINAPANT [WHO-DD];NSC-764757;D1143;EN300-25327900;DTXSID50648496;J-501625;D12565;SCHEMBL2724374;EX-A104;AC-30282;Q27074566;AT-406(AT406);(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo[1,2-a][1,5 ]diazocine-8-carboxamide;SM-406;NCGC00346675-03;DeBio-1143 (AT-406);Debio1143;Xevinapant [INN];AT-406Xevinapant?;AT406 (SM-406, ARRY-334543);CCG-270056;1071992-99-8, 1071992-57-8 (HCl);(5S,8S,10aR)-N-(diphenylmethyl)-5-[(2S)-2-(methylamino)propanamido]-3-(3-methylbutanoyl)-6-oxo-decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide;MFCD22124467;Xevinapant (JAN/USAN/INN);Z2740129972;HY-15454;(5S,8S,10aR)-N-(diphenylmethyl)-5-[(2S)-2-(methylamino)propanamido]-3-(3-methylbutanoyl)-6-oxo-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide;NSC764757;Pyrrolo[1,2-a][1,5]diazocine-8-carboxamide, N-(diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxo-, (5S,8S,10aR)-;D 1143;(5S,8S,10aR)-N-(diphenylmethyl)-5-[(2S)-2-(methylamino)propanamido]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide;AS-56453;Iap inhibitor AT-406;PYRROLO(1,2-A)(1,5)DIAZOCINE-8-CARBOXAMIDE, N-(DIPHENYLMETHYL)DECAHYDRO-5-(((2S)-2-(METHYLAMINO)-1-OXOPROPYL)AMINO)-3-(3-METHYL-1-OXOBUTYL)-6-OXO-, (5S,8S,10AR)-;BCP04668;(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-(((2S)-2-(methylamino)-1-oxopropyl)amino)-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo(1,2-a)(1,5)diazocine-8-carboxamide;DA-61281;Second Mitochondrial-derived Activator of Caspases Mimetic Debio 1143;CS-0962;D-1143;Debio-1143;SMAC Mimetic Debio 1143;IAPs Antagonist Debio 1143;IAPs Inhibitor Debio 1143;1071992-99-8;Pyrrolo(1,2-a)(1,5)diazocine-8-carboxamide, n-((1,1'-biphenyl)-2-ylmethyl)decahydro-5-(((2s)-2-(methylamino)-1-oxopropyl)amino)-3-(3-methyl-1-oxobutyl)-6-oxo-, (5s,8s,10ar);CHEMBL2158051;AKOS027250726;AT-406;1071992-99-8 (free base)
SMILES:	O=C1[C@H](CN(C(CC(C)C)=O)CC[C@H]2CC[C@@H](C(NC(C3C=CC=CC=3)C3C=CC=CC=3)=O)N21)NC([C@H](C)NC)=O
Formula:	C₃₂H₄₃N₅O₄
M.Wt:	561.714927911758
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC73115	DEBIO 1143	DEBIO 1143 (Xevinapant, AT-406, SM406, ARRY-334543, D1143) is a potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.