DU011|CAS 890818-51-6|DC Chemicals

Cas No.:	890818-51-6
Chemical Name:	DU011
Synonyms:	DU 011
SMILES:	O=C(C1=C(NC(C2=C(F)C=CC=C2F)=O)C=C(C3=CC=C(OCC)C=C3)S1)O
Formula:	C₂₀H₁₅F₂NO₄S
M.Wt:	403.400
Purity:	>97%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Arshad M, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01208-20.

Description:

DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli. DU011 does not alter Escherichia coli antibiotic resistance and has significantly enhanced inhibition of capsule expression, compared with other proposed MprA ligands, such as salicylate and 2,4-dinitrophenol (DNP).

References:

1. Arshad M, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01208-20.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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