Enbezotinib

  Cat. No.:  DC48424   Featured
Chemical Structure
2359649-81-1
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More than 5000 active chemicals with high quality for research!
Field of application
Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer.
Cas No.: 2359649-81-1
Chemical Name: Enbezotinib
SMILES: FC1=CC(CN2[C@H](CCC3)[C@H]3OC(C2=N4)=CN5C4=C6C=N5)=C(O[C@@H](C)CNC6=O)N=C1
Formula: C21H21FN6O3
M.Wt: 424.43
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.
Description: Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer[1].
In Vivo: Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice[1].
In Vitro: Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells[1].
References: [1]. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70734 RET agonist BT44 RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain.
DC48424 Enbezotinib Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer.
DC40968 LUN09945 LUN09945 is a potent RETV804M kinase inhibitor. LUN09945 was first reported by Rebecca Newton et al (Compound 13, in ACS Med Chem Lett. 2020;11(4):497-505). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature
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