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Endovion (NS 3728)

  Cat. No.:  DC47321   Featured
Chemical Structure
265646-85-3
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More than 5000 active chemicals with high quality for research!
Field of application
Endovion (NS 3728, SCO-101) is an potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 265646-85-3
Chemical Name: Endovion
Synonyms: Urea,N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]-;1-[3,5-bis(trifluoromethyl)phenyl]-3-[5-bromo-2-(2H-tetrazol-5-yl)phenyl]urea;1-[3,5-bis(Trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]urea;Endovion;N-(3,5-bis(Trifluoromethyl)phenyl)-N′-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)urea;NS 3728;NS-3728;NS3728;1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea;1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]urea;Endovion (NS 3728);GTPL4273;Q27088062;(N-[3,5-bis(trifluoromethyl)-phenyl]-N'-[4-bromo-2-(1h-tetrazol-5-yl)-phenyl] urea);BS-45868;AEFYFGMSRKDXHZ-UHFFFAOYSA-N;F77066;CHEMBL5314516;Emidurdar;HY-105917;N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(1H-tetrazol-5-yl)phenyl]urea;emidurdar [INN];SCHEMBL1463101;SCO-101;AKOS040741707;265646-85-3;EX-A9098;Endovion [WHO-DD];1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]urea;CS-0026942;SCO101;DA-52900
SMILES: BrC1C([H])=C([H])C(=C(C2N=NN([H])N=2)C=1[H])N([H])C(N([H])C1C([H])=C(C(F)(F)F)C([H])=C(C(F)(F)F)C=1[H])=O
Formula: C16H9BrF6N6O
M.Wt: 495.1767
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_31173_DC47321_265646-85-3
COA
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Cat. No. Product name Field of application
DC73605 TMinh-23 TMinh-23 is (Compound 10bm) is a potent, selective inhibitor of transmembrane protein 16A (TMEM16A or ANO1, DOG1, ORAOV2, TAOS-2) with IC50 of 30 nM in short-circuit current assays, weakly inhibits TMEM16B (IC50=400 nM, 13 -fold selectivity).
DC73604 TMEM16A blocker 1PBC 1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM).
DC73603 OV350 OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation.
DC70312 CLC-2-IN-AK42 CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2).AK42 displays unprecedented selectivity (>1,000-fold) over CLC-1, the closest CLC-2 homolog, and no off-target engagement a diverse panel of 61 CNS receptors, channels, and transporters expressed in brain tissue.AK-42 binds to an extracellular vestibule above the channel pore. AK-42 is almost three orders-of-magnitude more potent than MCFA, demonstrates high potency (IC50=14 nM for rat CLC-2) in manual patch-clamp experiments on CHO cells transiently transfected with rat CLC-2.AK-42 inhibits hyperpolarization-activated current in hippocampal cells, attenuates steady-state currents and eliminated relaxation currents in recorded neurons.AK-42 is a powerful tool for investigating CLC-2 neurophysiology.
DC47321 Endovion (NS 3728) Endovion (NS 3728, SCO-101) is an potent anion channel inhibitor that blocks the Volume Regulated Anion Channels (VRAC).
DC29060 Picrotoxinin Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors.
DC11173 DRAinh-A250 DRAinh-A250 is a specific inhibitor of Cl-/anion exchanger SLC26A3 (DRA), fully and reversibly inhibits SLC26A3-mediated Cl- exchange with HCO3-, I-, and thiocyanate (SCN-) with IC50 of ~0.2 uM.
DC11507 CLP257 CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM; displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors; restores impaired Cl(-) transport i
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